#600: Finite Knowledge, Infinite Ignorance

#600: Finite Knowledge, Infinite Ignorance

"The more we learn about the world, and the deeper our learning, the more conscious, specific, and articulate will be our knowledge of what we do not know, our knowledge of our ignorance. For this, indeed, is the main source of our ignorance — the fact that our knowledge can be only finite, while our ignorance must necessarily be infinite." – Karl Popper

To mark Sigma Nutrition's milestone 600th episode (and 12-year anniversary), Danny and Alan examine several areas in which their views have changed, softened, strengthened, or remained stable over the lifespan of the podcast.

The discussion is therefore not only about nutrition itself, but also about the process of scientific reasoning: how positions are formed, what type of evidence can shift them, and why changing one's mind is often a sign of better thinking rather than inconsistency.

The episode therefore serves as both a review of several specific nutrition controversies and a lesson in scientific epistemology. They discuss topics such as red meat, protein, dietary cholesterol, omega-3s, flavonoids, and sodium.

Timestamps
  • [11:04] Time-restricted eating
  • [19:32] Protein intake, quality & dosing
  • [35:04] Cocoa flavanols and cognition
  • [51:38] Unprocessed red meat
  • [01:05:23] Omega-3 supplementation
  • [01:23:10] Dietary cholesterol
  • [01:44:41] Sodium J-curve myth
  • [01:53:41] Energy balance model

Links

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Episoder(642)

#619: How Much Fish Should a Healthy Diet Contain?

#619: How Much Fish Should a Healthy Diet Contain?

Most dietary guidelines recommend eating one to two servings of fish per week, often specifying that at least one serving should be oily fish. But how directly is that recommendation supported by evid...

8 Sep 1h 3min

#618: How Wellness & Optimisation Culture Can Commodify Science – Nick Tiller, PhD

#618: How Wellness & Optimisation Culture Can Commodify Science – Nick Tiller, PhD

Wellness and optimisation culture increasingly presents itself as "science-based". But citing studies, using technical language, or having scientific credentials does not guarantee that the underlying...

1 Sep 56min

#617: What Does Effective Athlete Support Look Like in Practice? – Gemma McGuinness

#617: What Does Effective Athlete Support Look Like in Practice? – Gemma McGuinness

Effective athlete support requires more than delivering technically correct nutrition advice. It depends on understanding the athlete's wider environment, anticipating the pressures that disrupt good ...

25 Aug 46min

Fiber: Independent Benefits or Just a Proxy for Healthy Foods?

Fiber: Independent Benefits or Just a Proxy for Healthy Foods?

This episode answers one of the questions raised in the most recent Q&A episode on Sigma Nutrition Premium.  The full episode includes the following questions: Fiber: Independent effect or proxy for ...

18 Aug 21min

#616: More Testing, Better Health? Harms of Overdiagnosis & Overtreatment - Austin Baraki, MD

#616: More Testing, Better Health? Harms of Overdiagnosis & Overtreatment - Austin Baraki, MD

Medical screening is often framed as an uncomplicated good: if disease is found earlier, treatment can begin earlier and outcomes should improve. This episode examines why that reasoning is incomplete...

11 Aug 1h 15min

#615: Why Processing Doesn't Determine the Healthfulness of Plant-Based Diets – Alysha Thompson, PhD

#615: Why Processing Doesn't Determine the Healthfulness of Plant-Based Diets – Alysha Thompson, PhD

What does the evidence actually show when we look at plant-based dietary patterns through the lens of food processing? And does classifying foods as "ultra-processed" meaningfully change how we interp...

4 Aug 56min

#614: The Human Skills of Nutrition Coaching – Krista Scott-Dixon, PhD

#614: The Human Skills of Nutrition Coaching – Krista Scott-Dixon, PhD

In nutrition and health coaching, one of the central challenges is understanding how people actually change, particularly when life is complex, motivation fluctuates, and behaviour is shaped by emotio...

21 Jul 56min

#613: Supplement Safety & Medication Interactions – Giulia Guerrini, MPharm

#613: Supplement Safety & Medication Interactions – Giulia Guerrini, MPharm

Supplement safety is often discussed in very general terms, but in practice the risks depend heavily on the individual. A supplement that is reasonable for one person may be inappropriate for another ...

14 Jul 57min

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