Too Much Histamine Is Wrecking Your Body — And Most Doctors Don't Know It

Histamine isn't just about seasonal allergies or a runny nose. It influences your brain, gut, hormones, immune system, and nervous system—and when your body can't regulate it properly, it can show up as everything from anxiety and migraines to insomnia, digestive issues, skin rashes, and brain fog. In this episode, I explain why histamine overload happens, how it relates to Mast Cell Activation Syndrome (MCAS), and what a root-cause approach looks like for calming an overactive immune system. In today's episode, I discuss: * Why MCAS and histamine intolerance are different—and how overactive mast cells can drive symptoms ranging from migraines and anxiety to digestive issues, hives, and heart palpitations * The hidden triggers behind mast cell activation, including gut dysfunction, chronic infections, mold exposure, hormone imbalances, stress, and environmental toxins * Why many "healthy" foods like avocados, spinach, tomatoes, kombucha, and bone broth can temporarily worsen symptoms when your histamine bucket is already full * A root-cause approach to calming the immune system using nutrition, targeted supplements, medications when needed, nervous system regulation, and addressing the underlying drivers of inflammation MCAS isn't simply a histamine problem—it's a sign that your immune system has become dysregulated. Instead of just suppressing symptoms, the goal is to understand why your mast cells are overreacting in the first place. When you lower the overall inflammatory load and restore balance to the gut, immune system, hormones, and nervous system, you create the conditions for lasting healing rather than temporary symptom relief. Resources Mentioned: * Track your biomarkers with Function Health: https://functionhealth.com/mark (Use code MARK2026 for $50 off your membership.) * Have a question you’d love answered on Office Hours? Submit it here