#70 - Dr Cassidy Nelson on the 12 best ways to stop the next pandemic (and limit nCoV)

#70 - Dr Cassidy Nelson on the 12 best ways to stop the next pandemic (and limit nCoV)

nCoV is alarming governments and citizens around the world. It has killed more than 1,000 people, brought the Chinese economy to a standstill, and continues to show up in more and more places. But bad though it is, it's much closer to a warning shot than a worst case scenario. The next emerging infectious disease could easily be more contagious, more fatal, or both.

Despite improvements in the last few decades, humanity is still not nearly prepared enough to contain new diseases. We identify them too slowly. We can't do enough to reduce their spread. And we lack vaccines or drugs treatments for at least a year, if they ever arrive at all.

Links to learn more, summary and full transcript.

This is a precarious situation, especially with advances in biotechnology increasing our ability to modify viruses and bacteria as we like.

In today's episode, Cassidy Nelson, a medical doctor and research scholar at Oxford University's Future of Humanity Institute, explains 12 things her research group think urgently need to happen if we're to keep the risk at acceptable levels. The ideas are:

Science

1. Roll out genetic sequencing tests that lets you test someone for all known and unknown pathogens in one go.
2. Fund research into faster ‘platform’ methods for going from pathogen to vaccine, perhaps using innovation prizes.
3. Fund R&D into broad-spectrum drugs, especially antivirals, similar to how we have generic antibiotics against multiple types of bacteria.

Response

4. Develop a national plan for responding to a severe pandemic, regardless of the cause. Have a backup plan for when things are so bad the normal processes have stopped working entirely.
5. Rigorously evaluate in what situations travel bans are warranted. (They're more often counterproductive.)
6. Coax countries into more rapidly sharing their medical data, so that during an outbreak the disease can be understood and countermeasures deployed as quickly as possible.
7. Set up genetic surveillance in hospitals, public transport and elsewhere, to detect new pathogens before an outbreak — or even before patients develop symptoms.
8. Run regular tabletop exercises within governments to simulate how a pandemic response would play out.

Oversight

9. Mandate disclosure of accidents in the biosafety labs which handle the most dangerous pathogens.
10. Figure out how to govern DNA synthesis businesses, to make it harder to mail order the DNA of a dangerous pathogen.
11. Require full cost-benefit analysis of 'dual-use' research projects that can generate global risks.

12. And finally, to maintain momentum, it's necessary to clearly assign responsibility for the above to particular individuals and organisations.

These advances can be pursued by politicians and public servants, as well as academics, entrepreneurs and doctors, opening the door for many listeners to pitch in to help solve this incredibly pressing problem.

In the episode Rob and Cassidy also talk about:

• How Cassidy went from clinical medicine to a PhD studying novel pathogens with pandemic potential.
• The pros, and significant cons, of travel restrictions.
• Whether the same policies work for natural and anthropogenic pandemics.
• Ways listeners can pursue a career in biosecurity.
• Where we stand with nCoV as of today.

Chapters:

  • Rob’s intro (00:00:00)
  • The interview begins (00:03:27)
  • Where we stand with nCov today (00:07:24)
  • Policy idea 1: A drastic change to diagnostic testing (00:34:58)
  • Policy idea 2: Vaccine platforms (00:47:08)
  • Policy idea 3: Broad-spectrum therapeutics (00:54:48)
  • Policy idea 4: Develop a national plan for responding to a severe pandemic, regardless of the cause (01:02:15)
  • Policy idea 5: A different approach to travel bans (01:15:59)
  • Policy idea 6: Data sharing (01:16:48)
  • Policy idea 7: Prevention (01:24:45)
  • Policy idea 8: transparency around lab accidents (01:33:58)
  • Policy idea 9: DNA synthesis screening (01:39:22)
  • Policy idea 10: Dual Use Research oversight (01:48:47)
  • Policy idea 11: Pandemic tabletop exercises (02:00:00)
  • Policy idea 12: Coordination (02:12:20)


Get this episode by subscribing: type 80,000 Hours into your podcasting app. Or read the linked transcript.

Producer: Keiran Harris.
Transcriptions: Zakee Ulhaq.

Episoder(300)

#3 - Dario Amodei on OpenAI and how AI will change the world for good and ill

#3 - Dario Amodei on OpenAI and how AI will change the world for good and ill

Just two years ago OpenAI didn’t exist. It’s now among the most elite groups of machine learning researchers. They’re trying to make an AI that’s smarter than humans and have $1b at their disposal. Even stranger for a Silicon Valley start-up, it’s not a business, but rather a non-profit founded by Elon Musk and Sam Altman among others, to ensure the benefits of AI are distributed broadly to all of society.  I did a long interview with one of its first machine learning researchers, Dr Dario Amodei, to learn about: * OpenAI’s latest plans and research progress. * His paper *Concrete Problems in AI Safety*, which outlines five specific ways machine learning algorithms can act in dangerous ways their designers don’t intend - something OpenAI has to work to avoid. * How listeners can best go about pursuing a career in machine learning and AI development themselves. Full transcript, apply for personalised coaching to work on AI safety, see what questions are asked when, and read extra resources to learn more. 1m33s - What OpenAI is doing, Dario’s research and why AI is important  13m - Why OpenAI scaled back its Universe project  15m50s - Why AI could be dangerous  24m20s - Would smarter than human AI solve most of the world’s problems?  29m - Paper on five concrete problems in AI safety  43m48s - Has OpenAI made progress?  49m30s - What this back flipping noodle can teach you about AI safety  55m30s - How someone can pursue a career in AI safety and get a job at OpenAI  1h02m30s - Where and what should people study?  1h4m15s - What other paradigms for AI are there?  1h7m55s - How do you go from studying to getting a job? What places are there to work?  1h13m30s - If there's a 17-year-old listening here what should they start reading first?  1h19m - Is this a good way to develop your broader career options? Is it a safe move?  1h21m10s - What if you’re older and haven’t studied machine learning? How do you break in?  1h24m - What about doing this work in academia?  1h26m50s - Is the work frustrating because solutions may not exist?  1h31m35s - How do we prevent a dangerous arms race?  1h36m30s - Final remarks on how to get into doing useful work in machine learning

21 Jul 20171h 38min

#2 - David Spiegelhalter on risk, stats and improving understanding of science

#2 - David Spiegelhalter on risk, stats and improving understanding of science

Recorded in 2015 by Robert Wiblin with colleague Jess Whittlestone at the Centre for Effective Altruism, and recovered from the dusty 80,000 Hours archives. David Spiegelhalter is a statistician at the University of Cambridge and something of an academic celebrity in the UK. Part of his role is to improve the public understanding of risk - especially everyday risks we face like getting cancer or dying in a car crash. As a result he’s regularly in the media explaining numbers in the news, trying to assist both ordinary people and politicians focus on the important risks we face, and avoid being distracted by flashy risks that don’t actually have much impact. Summary, full transcript and extra links to learn more. To help make sense of the uncertainties we face in life he has had to invent concepts like the microlife, or a 30-minute change in life expectancy. (https://en.wikipedia.org/wiki/Microlife) We wanted to learn whether he thought a lifetime of work communicating science had actually had much impact on the world, and what advice he might have for people planning their careers today.

21 Jun 201733min

#1 - Miles Brundage on the world's desperate need for AI strategists and policy experts

#1 - Miles Brundage on the world's desperate need for AI strategists and policy experts

Robert Wiblin, Director of Research at 80,000 Hours speaks with Miles Brundage, research fellow at the University of Oxford's Future of Humanity Institute. Miles studies the social implications surrounding the development of new technologies and has a particular interest in artificial general intelligence, that is, an AI system that could do most or all of the tasks humans could do. This interview complements our profile of the importance of positively shaping artificial intelligence and our guide to careers in AI policy and strategy Full transcript, apply for personalised coaching to work on AI strategy, see what questions are asked when, and read extra resources to learn more.

5 Jun 201755min

#0 – Introducing the 80,000 Hours Podcast

#0 – Introducing the 80,000 Hours Podcast

80,000 Hours is a non-profit that provides research and other support to help people switch into careers that effectively tackle the world's most pressing problems. This podcast is just one of many things we offer, the others of which you can find at 80000hours.org. Since 2017 this show has been putting out interviews about the world's most pressing problems and how to solve them — which some people enjoy because they love to learn about important things, and others are using to figure out what they want to do with their careers or with their charitable giving. If you haven't yet spent a lot of time with 80,000 Hours or our general style of thinking, called effective altruism, it's probably really helpful to first go through the episodes that set the scene, explain our overall perspective on things, and generally offer all the background information you need to get the most out of the episodes we're making now. That's why we've made a new feed with ten carefully selected episodes from the show's archives, called 'Effective Altruism: An Introduction'. You can find it by searching for 'Effective Altruism' in your podcasting app or at 80000hours.org/intro. Or, if you’d rather listen on this feed, here are the ten episodes we recommend you listen to first: • #21 – Holden Karnofsky on the world's most intellectual foundation and how philanthropy can have maximum impact by taking big risks • #6 – Toby Ord on why the long-term future of humanity matters more than anything else and what we should do about it • #17 – Will MacAskill on why our descendants might view us as moral monsters • #39 – Spencer Greenberg on the scientific approach to updating your beliefs when you get new evidence • #44 – Paul Christiano on developing real solutions to the 'AI alignment problem' • #60 – What Professor Tetlock learned from 40 years studying how to predict the future • #46 – Hilary Greaves on moral cluelessness, population ethics and tackling global issues in academia • #71 – Benjamin Todd on the key ideas of 80,000 Hours • #50 – Dave Denkenberger on how we might feed all 8 billion people through a nuclear winter • 80,000 Hours Team chat #3 – Koehler and Todd on the core idea of effective altruism and how to argue for it

1 Mai 20173min

Populært innen Fakta

fastlegen
dine-penger-pengeradet
hanna-de-heldige
fryktlos
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
treningspodden
foreldreradet
dypdykk
rss-strid-de-norske-borgerkrigene
jakt-og-fiskepodden
tomprat-med-gunnar-tjomlid
sinnsyn
hverdagspsyken
rss-kunsten-a-leve
rss-sunn-okonomi
gravid-uke-for-uke
mikkels-paskenotter
doktor-fives-podcast
rss-mann-i-krise-med-sagen
historietimen