#81 - Aging, Alzheimer’s, and Sleep with Dr. William Jagust

#81 - Aging, Alzheimer’s, and Sleep with Dr. William Jagust

Dr. William “Bill” Jagust, renowned expert in brain science and Alzheimer’s research - and one of the reasons Matt chose to move to UC Berkeley - joins our host today for an in-depth discussion on aging, cognitive decline, and the critical role of neuroimaging, with some sleep talk woven in as well. Dr. Jagust shares groundbreaking insights into how PET scans can detect amyloid and tau proteins in the brain—two key contributors to Alzheimer’s disease—years before symptoms emerge. Together wit...

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Episoder(187)

The Night Ferryman: A Sleep Story Read by Matt Walker

The Night Ferryman: A Sleep Story Read by Matt Walker

Join Matt for a serene excursion across a valley lake under the cover of night. After finding a comfortable position and centering your breath, you will step onto the deck of a weathered ferry. Marcus...

31 Aug 35min

#149 - The 11 largest Sleep Myths

#149 - The 11 largest Sleep Myths

Debunking 11 sleep myths, Matt begins by explaining that the brain remains active, not "off," during rest. He goes on to argue that 7-9 hours of sleep is vital and warns that "adapting" to less is a d...

24 Aug 27min

#148 - Psychedelics for Mental Health

#148 - Psychedelics for Mental Health

Matt delves into how psychedelics like psilocybin and LSD quiet the "Default Mode Network" to boost neuroplasticity. He describes these molecules as a "crowbar" that allows therapy to break deep-seate...

17 Aug 32min

#147 - Does Sleep Really Clean Your Brain?

#147 - Does Sleep Really Clean Your Brain?

Matt explores the brain's secret plumbing, a waste-clearance network once ignored for over a century. He explains how the glymphatic system flushes metabolic toxins like amyloid-beta during sleep. Thi...

10 Aug 25min

#146 - How Sleep Changes Across the Human Lifespan

#146 - How Sleep Changes Across the Human Lifespan

Matt tracks sleep across the human lifespan, from newborn "active sleep" to the shifts of healthy aging. He explores how biological milestones - like puberty, pregnancy, and menopause - impact rest, r...

3 Aug 20min

#145 - How to get More Deep Sleep

#145 - How to get More Deep Sleep

Matt explains the science of deep sleep, emphasizing that this front-loaded stage is vital for physical and mental repair. To boost it, he recommends "builders" like consistent wake times, daily exerc...

27 Jul 32min

#144 - Face Blindness Explained

#144 - Face Blindness Explained

Matt explores how the brain constructs reality by examining neurological anomalies. He contrasts "super-recognizers" with those living with prosopagnosia, or face blindness. By analyzing the Capgras d...

20 Jul 28min

#143 - The Science of Love, Desire, and Sex

#143 - The Science of Love, Desire, and Sex

Matt examines the neurobiology of love, defining it as a reward system rather than just an emotion. He breaks love into three systems: lust (hormones), attraction (dopamine), and attachment (oxytocin)...

13 Jul 33min

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