Man, Mosquito, Malaria Vaccine
a16z Podcast2 Mai 2021

Man, Mosquito, Malaria Vaccine

Playing out against the backdrop of a global pandemic (including recent massive surges in regions around the world) is the news that came out a week ago that a candidate "malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal”. While the findings are still in preprint with The Lancet, the resulting buzz and phrases quoted included everything from “unprecedented”, “groundbreaking work”, and “very exciting” to “high expectations”, “highly effective”, and “a hugely significant extra weapon”... A "weapon" in the war against malaria that is -- a disease that is estimated to cause over 400,000 deaths each year globally, and predominantly in children under the age of five.

So in this special 2x explainer episode of 16 Minutes (also running on the a16z Podcast), we -- Rajeev Venkayya of Takeda Pharmaceuticals, a16z bio general partner Jorge Conde, and Sonal Chokshi -- dig into what's hype/ what's real about this news, beyond the headlines and beyond the buzz. What does the data tell us, what does the current study phase mean, and what's left to get to widespread, real-world use? How does this candidate vaccine (R21 from Jenner Institute/ Oxford University) compare to the other malaria vaccine (RTS,S from GlaxoSmithKline)? How do, and don't, advances in and around COVID vaccines play here? And why has it been so hard to develop vaccines for this particular disease?

Because we also cover (as is the premise of the show) where we are on the long arc of innovation... and this is an innovation story that's been nearly a century in the making.

Episoder(904)

a16z Podcast: The Apple WWDC 2014 Deep Dive

a16z Podcast: The Apple WWDC 2014 Deep Dive

Benedict Evans is a veteran of Apple’s big events and puts all the announcements and demos into one of three categories: 1) all the cool incremental improvements to the Apple operating systems; 2) the tent-pole features that Apple likes to build marketing campaigns around; 3) and finally, the fundamental strategic moves by Apple that serve to push the company ahead of the competition. With help from Andreessen Horowitz technical talent partner Dave Jagoda, this segment picks apart all three categories.

3 Jun 201423min

a16z Podcast: You Just Thought You Were Building a Software Company. It's a Community.

a16z Podcast: You Just Thought You Were Building a Software Company. It's a Community.

For Jim Gilliam, the founder of NationBuilder, community is everything. When he needed a double lung transplant, Gilliam turned to the Internet and to his online community to make it happen. He's organized political campaigns, made documentary films, and built his company NationBuilder by tapping into the power that large scale communities on the internet provide. Community at internet scale is a deep reservoir of people, ideas and yes, money, that Gilliam believes changes how we do almost everything - and makes almost anything possible.

30 Mai 20149min

a16z Podcast: Bending Every Pixel to Your Will -- Optimizely and the Next Wave of Internet Tools

a16z Podcast: Bending Every Pixel to Your Will -- Optimizely and the Next Wave of Internet Tools

Optimizely is a superb example of the democratization of software development. You don't need an engineering degree to fire up Optimizely and start testing how design changes on your website -- down to the pixel level -- affect things like time on site, closing sales, navigation, etc. The a/b testing Optimizely offers is just one example of a new wave of tools born of the internet, and designed for how people work, shop, research and entertain themselves online. Andreessen Horowitz's Scott Weiss, who is taking a seat on the Optimizely board following a16z's recent investment, a16z Partner Tom Rikert, and Optimizely co-founder Dan Siroker discuss the next wave of internet tools, where entrepreneurs are headed next, and how virtually anyone can avail themselves of this technical brawn.

20 Mai 201420min

a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

a16z Podcast: The Two Big Problems With Thomas Piketty’s “Capital in the Twenty-First Century”

“At a moment of great concern about inequality, now comes a learned tome proclaiming the gravity of the inequality problem,” says Larry Summers in a conversation with Andreessen Horowitz’s Balaji Srinivasan. “It’s a stunning thing, and it must reflect positively on the growing intellectualism of the society that a book like that could be a best-seller.” But that doesn’t mean Piketty got it right, adds the former Secretary of the Treasury and current a16z special advisor. Summers describes the two big problems he sees with Piketty’s argument, and how the forces of technology and globalization are better lenses through which to view and explain income inequality.

15 Mai 201415min

a16z Podcast: Demystifying Venture Capital

a16z Podcast: Demystifying Venture Capital

What do venture capitalists actually do all day? And what is the path that leads to a career investing in startups? Hummer Winblad’s Ann Winblad, Cowboy Ventures' Aileen Lee, Aspect Ventures' Theresia Gouw, Intel Capital veteran and UPWARD founder Lisa Lambert, and Andreessen Horowitz’s Margit Wennmachers discuss VC trends, the importance of technical chops, and how to build the next generation of entrepreneurs and investors. And finally, in front of an appreciative crowd attending the UPWARD event at a16z, Ann Winblad reveals the secret to truly kicking ass.

2 Mai 201437min

a16z Podcast: When Your PC Expires, What's Next?

a16z Podcast: When Your PC Expires, What's Next?

Computing is in the midst of a transformation that puts your future device purchases up for grabs. It’s a safe bet that everyone will have a phone, and as the last holdouts switch over, that will inevitably mean a smartphone. But when your PC finally gives up the ghost, are you going to buy another PC? Perhaps a tablet? Or will another large screen device –a really big phone - be the ticket? Maybe just get all three? Benedict Evans and Steven Sinofsky discuss why laptops and tablets are competing for the same customers, and why it’s never wise to defend any form-factor to the death.

30 Apr 201416min

a16z Podcast: Apple and the Fate of Tablets

a16z Podcast: Apple and the Fate of Tablets

Apple’s recent earnings sent the stock soaring. What drove that investor exuberance had everything to do with iPhone sales (and the China market), and very little to do with the iPad – the sales of which were essentially flat over the past year. Chris Dixon and Benedict Evans look at the fortunes of the world’s best-selling tablet, and what that means for the balance of power in the computing world. Are smartphones supplanting tablets for most uses? Are developers so focused on creating apps for the latest handsets the tablet is becoming an afterthought?

25 Apr 201421min

a16z Podcast: The Future Of Television

a16z Podcast: The Future Of Television

Can technology companies show up and disrupt television with an onslaught of new gizmos and services, or is content still the controlling factor? What will it take in terms of money, business model and time to upend the TV model that has stubbornly persisted for decades? Will the old platforms and players dominate, or is now the time for new players to take charge? Andreessen Horowitz’s Benedict Evans and Zal Bilimoria discuss the future of television.

18 Apr 201419min

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