Is Obesity A Muscle Problem?
Muscle is where most of the glucose goes, and muscle insulin resistance is the first thing that breaks on the road to type 2 diabetes. Both of those are true, and neither one means that building more ...
4 Sep 1h 17min
Who Needs Testosterone, and Who's Not Getting It I Signal Episode 4
Most men who start testosterone never needed it, and some who genuinely do never get treated. In the final episode of the Signal series, Dr. Jordan Feigenbaum and Dr. Austin Baraki work through who ac...
27 Aug 1h 26min
Your Fat Has a Storage Limit
In 2004 a surgeon removed about ten kilograms of fat from fifteen women and measured everything that mattered. Nothing improved. Four years later, it still hadn't.That result should have ended an argu...
20 Aug 49min
Lifting and longevity: is 1 hour a week really the limit? Plus GLP1s and mood, training with ME/CFS, and Protein vs. Calories
A popular paper claimed the longevity benefit of lifting disappears once you train more than an hour a week. It's a real paper, but the claim is a misread. This is the free cut of this month's Direct ...
12 Aug 46min
The FDA Voted for 6 Peptides. Its Own Scientists Said No
An FDA advisory committee just voted to open a legal compounding supply line for six of seven peptides, including BPC-157 and TB-500, over the objection of the FDA's own scientists, who recommended ag...
7 Aug 1h 6min
The Man Who Couldn’t Stop Gaining Weight | A Medical Mystery
A previously healthy 21-year-old shows up with seven months of headaches and 30-plus pounds of weight gain he can’t explain. He’s eating the same and training more, and the scale climbs anyway. We han...
31 Jul 1h 10min
The Protein Scaries: What the Research Says About Your Kidneys, Cancer, Bones, and Body Fat
Every couple of years a new headline warns that the protein you eat is quietly hurting you. This year the target is your kidneys. Before that it was cancer, then your bones, then the claim that your b...
24 Jul 32min
Is It Really Just Calories In, Calories Out? Metabolism, Insulin, Hormones and Why Counting Fails
Is weight loss really just Calories in, Calories out? The equation is true, but "just count your Calories" is bad advice for most people, and almost every objection to it is pointing at something real...
17 Jul 31min
