#080: B-Cell Depletion – Ocrelizumab (Ocrevus), Ofatumumab (Kesimpta, Bonspri), Rituximab (Mabthera, Rituxan), Ublituximab (Briumvi) for active RRMS and SPMS, and early PPMS

#080: B-Cell Depletion – Ocrelizumab (Ocrevus), Ofatumumab (Kesimpta, Bonspri), Rituximab (Mabthera, Rituxan), Ublituximab (Briumvi) for active RRMS and SPMS, and early PPMS

Learn more about b-cell depletion, including Ocrevus, Kesimpta, Bonspri, Mabthera, Rituxan, and Briumvi, used for active RRMS, SPMS, and PPMS.

You can read the full article on my blog: https://ms-perspektive.com/080-b-cell-depletion

B-cell depletion therapies such as ocrelizumab (Ocrevus), ofatumumab (Kesimpta, Bonspri), rituximab (Mabthera, Rituxan) and ublituximab (Briumvi) have become important tools in the treatment of multiple sclerosis (MS). These treatments specifically target and deplete B cells, a type of immune cell involved in the inflammatory process of MS. B-cell therapies are considered to be some of the most specific and potent disease-modifying therapies (DMTs) available today, offering a tailored approach to reducing disease activity and progression. In this blog, we will explore how these therapies are classified within MS treatment options and what their approval status and efficacy mean for different patient populations.

Please remember that I can only provide an overview here. Your neurologist and your MS nurse should advise you in detail on the right therapy for you. This is because they know your general state of health and you should also talk about your goals, wishes, fears and preferences so that these can be taken into account.

You may also want to look at the posts on the other DMTs:

See you soon and try to make the best out of your life,
Nele

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Episoder(184)

#182: How excercise can influence multiple sclerosis – interview with Prof. Dr. Dr. Philipp Zimmer

#182: How excercise can influence multiple sclerosis – interview with Prof. Dr. Dr. Philipp Zimmer

This episode is the English translation and adaptation of my original German interview with Prof. Dr. Dr. Philipp Zimmer, first published in August 2023. Prof. Zimmer is a sports scientist, neuroscien...

9 Sep 38min

#181: Stress and MS: factors, challenges and perspectives with Prof. Sigrid Arnade and Prof. Christoph Heesen

#181: Stress and MS: factors, challenges and perspectives with Prof. Sigrid Arnade and Prof. Christoph Heesen

This episode is the English translation of my original German interview with Prof. Sigrid Arnade and Prof. Christoph Heesen, first published in April 2025. We explore what research currently tells us ...

2 Sep 34min

#180: Cannabis and multiple sclerosis. Benefits, risks, CHS and what you should know

#180: Cannabis and multiple sclerosis. Benefits, risks, CHS and what you should know

Cannabis is a popular and often emotional topic in the MS community. Some people hope it may help with spasticity, pain, sleep or other symptoms, while others are concerned about side effects, cogniti...

26 Aug 41min

#179: Multiple Sclerosis without the noise. Dominic Shadbolt on 35 years with MS, treatment and real patient involvement

#179: Multiple Sclerosis without the noise. Dominic Shadbolt on 35 years with MS, treatment and real patient involvement

What does living with multiple sclerosis for 35 years teach you about treatment, disability, information and the role MS should have in your life? In this episode, I talk with Dominic Shadbolt, founde...

19 Aug 1h 5min

#178: Tai Chi and Qigong for MS: Supporting Balance, Movement and Body Awareness – Interview with Mirko Lorenz

#178: Tai Chi and Qigong for MS: Supporting Balance, Movement and Body Awareness – Interview with Mirko Lorenz

Tai Chi and Qigong can be gentle, adaptable ways to support balance, coordination, mobility and body awareness in people with multiple sclerosis. In this episode, I talk with Tai Chi instructor Mirko...

12 Aug 25min

#177: A First Diagnosis of Multiple Sclerosis: Symptoms, Tests, and Next Steps

#177: A First Diagnosis of Multiple Sclerosis: Symptoms, Tests, and Next Steps

What may be the first signs of multiple sclerosis? Which tests are needed to diagnose MS, and what happens after the diagnosis? In this episode, I speak with Dr Datzmann, Senior Consultant at the MS C...

5 Aug 22min

#176: Progressive MS Research: Milestones, Setbacks and Hope with Tim Coetzee

#176: Progressive MS Research: Milestones, Setbacks and Hope with Tim Coetzee

Progressive MS research has made important advances, but many questions about disability progression, biomarkers, treatment, and quality of life remain unanswered. In this episode, I speak with Tim Co...

22 Jul 56min

#175: Multiple Sclerosis and Pain. How Exercise and Physical Activity Can Help

#175: Multiple Sclerosis and Pain. How Exercise and Physical Activity Can Help

Pain is one of the most common and life-impacting symptoms in multiple sclerosis. In this episode, Nele talks with Rasmus Christian Jungersen, PhD student at the Department of Exercise Biology at Aarh...

15 Jul 1h 8min

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