Lead: Bitter sensing protects Drosophila from developing experience-dependent cocaine consumption preference

Lead: Bitter sensing protects Drosophila from developing experience-dependent cocaine consumption preference

Bitter sensing protects Drosophila from developing experience-dependent cocaine consumption preference

The Journal of Neuroscience

Cocaine use disorder (CUD) is a highly heritable condition for which there are no effective treatments. Testing the many human genetic variants linked to CUD requires a cost-effective, genetically tractable model. This study showed that bitter-sensing neurons prevent cocaine self-administration in Drosophila. Disrupting Drosophila bitter perception enables a model for experience-dependent cocaine preference. The findings underscore the potential of Drosophila as a crucial tool for identifying the genetic mechanisms underlying CUD, aiding in the discovery of new therapeutic targets, and contributing to the development of effective treatments for this highly heritable disease.

Read this issue of the ASAM Weekly

Subscribe to the ASAM Weekly

Visit ASAM

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(100)

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Lead: Oral semaglutide for alcohol use disorder: A randomized clinical trial

Oral Semaglutide for Alcohol Use Disorder: A Randomized Clinical Trial The American Journal of Psychiatry Accumulating preclinical and observational evidence suggests that glucagon-like peptide-1 rece...

25 Aug 7min

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Lead: Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic

Reflections on the preparation, implementation, and sustainability of a virtual SUD clinic: A public health response to the opioid epidemic Journal of Substance Use and Addiction Treatment This is an ...

18 Aug 7min

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Lead: Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis Addiction Cocaine use disorder (CUD) is an increasingly wi...

11 Aug 7min

Lead: 2025 National Survey on Drug Use and Health (NSDUH)

Lead: 2025 National Survey on Drug Use and Health (NSDUH)

2025 National Survey on Drug Use and Health (NSDUH) SAMHSA The 2025 National Survey on Drug Use and Health (NSDUH) shows encouraging trends among adolescents and young adults with broad declines acros...

4 Aug 7min

Lead: Association between GLP-1 receptor agonists and alcohol-related hospitalisations among adults with alcohol use disorder: Multi-target trial emulation study

Lead: Association between GLP-1 receptor agonists and alcohol-related hospitalisations among adults with alcohol use disorder: Multi-target trial emulation study

Association between GLP-1 receptor agonists and alcohol-related hospitalisations among adults with alcohol use disorder: Multi-target trial emulation study BMJ Open This retrospective cohort study usi...

28 Jul 6min

Lead: Trends in alcohol-related deaths in the United States over 55 years: 1968-2023

Lead: Trends in alcohol-related deaths in the United States over 55 years: 1968-2023

Trends in alcohol-related deaths in the United States over 55 years: 1968-2023 Alcohol, Clinical and Experimental Research  This study of alcohol-related mortality trends since 1968 used primarily dea...

21 Jul 6min

Lead: Comparison of buprenorphine treatment by virtual-only vs. traditional clinicians

Lead: Comparison of buprenorphine treatment by virtual-only vs. traditional clinicians

Comparison of buprenorphine treatment by virtual-only vs. traditional clinicians  Journal of Substance Use and Addiction Treatment  Few patients with opioid use disorder (OUD) receive medications for ...

14 Jul 7min

Lead: Adjunctive psychosocial interventions and opioid abstinence among patients receiving buprenorphine: A randomized clinical trial

Lead: Adjunctive psychosocial interventions and opioid abstinence among patients receiving buprenorphine: A randomized clinical trial

Adjunctive psychosocial interventions and opioid abstinence among patients receiving buprenorphine: A randomized clinical trial JAMA Network Open This randomized clinical trial of 340 adults with opio...

7 Jul 7min

Populært innen Politikk og nyheter

giver-og-gjengen-vg
aftenpodden
forklart
aftenpodden-usa
popradet
stopp-verden
lydartikler-fra-aftenposten
det-store-bildet
dine-penger-pengeradet
nokon-ma-ga
rss-gukild-johaug
hanna-de-heldige
rss-ness
rss-espen-lee-usensurert
fotballpodden-2
aftenbla-bla
rss-penger-polser-og-politikk
e24-podden
frokostshowet-pa-p5
unitedno