How to Build a Successful Company in an Era of Disruption

How to Build a Successful Company in an Era of Disruption

What happens when a startup becomes a giant—and then has to reinvent itself all over again?

In this episode, Martin Casado sits down with Raghu Raghuram (former CEO of VMware) and Jeetu Patel (President and CPO at Cisco) for a deep, tactical conversation on scaling, disruption, and navigating transformation from the inside. They share hard-won lessons from leading two of the most iconic infrastructure companies in tech—through waves like virtualization, cloud, containers, and now AI.

They cover:

  • How to keep innovation alive inside large companies
  • Why the best companies operate with a founder’s mindset, even without founders
  • The difference between selling to buyers vs. practitioners
  • Why the story is the strategy, and how to tell it at scale
  • How Cisco is rebuilding its startup DNA in the age of AI

If you're building or leading through a major tech wave, this episode is a playbook.

Timecodes:

0:00 Introduction

2:02 Weapons of Mass Disruption: Abstractions, Business Models, and Cloud

5:57 Cisco’s Missed Cloud Wave & Resetting for Innovation

6:39 Operating Like a Startup: Speed, Scale, and Leadership

10:00 Go-to-Market Challenges: Fencing Off Innovation

11:04 Organic vs. Inorganic Growth: Lessons from VMware

12:04 The 10x Rule and Competing with Incumbents

14:39 Structuring for Disruption: Two-Pizza Teams and Ideal Customer Profiles

18:43 Storytelling as Strategy: Galvanizing Large Organizations

19:42 The AI Wave: Consumerization and Infrastructure Demands

25:34 Founders vs. Operators: Leading Transformations

31:47 Product-Led Organizations: From Sales to Product Focus

34:35 The Future of Infrastructure: AI, Market Size, and Vertical Integration

39:34 Timing, Market, Team, Product, Brand, and Scale

41:19 Authenticity, Opportunity, and Final Thoughts

Resources:

Find Martin on X: https://x.com/martin_casado

Find Raghu on X: https://x.com/raghuraghuram

Find Jeetu on X: https://x.com/jpatel41

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Episoder(906)

a16z Podcast: Trade, Commerce, Manufacturing, Immigration, & Cuba -- with Penny Pritzker

a16z Podcast: Trade, Commerce, Manufacturing, Immigration, & Cuba -- with Penny Pritzker

"We really want Apple here... Would you please call Tim Cook?" That's just one of the things Penny Pritzker, the 38th Secretary of Commerce has heard as she and the U.S. Department of Commerce engage in "commercial diplomacy" around the world. Their job is to help overcome trade barriers, represent the interests of entrepreneurs and drive administrative policy change as it relates to technology, and be on the frontline of helping small and medium-sized businesses in markets all around the world -- from Indonesia to Europe to Cuba. So what else have they found about how other countries perceive U.S. tech companies? Especially as they wrangle with issues such as immigration (and not just for high-education visas); E.U. Safe Harbor (which is more difficult for smaller companies) and its update, the transatlantic Privacy Shield agreement; and finally, the TPP or Trans-Pacific Partnership multinational trade agreement (for which some have expressed intellectual property concerns)? And then... since the previous policy of isolation didn't work, how is the U.S. government's policy of engagement with Cuba working out so far? Priztker shares perspectives on all this and more in this episode -- including views on focusing on advanced manufacturing; gathering data from weather sensors and census surveys; and counting the gig economy in GDP -- with a16z's head of policy and regulatory affairs, Ted Ullyot. The conversation took place at Andreessen Horowitz' inaugural Silicon Valley comes to Washington, D.C. tech and policy event in April 2016.

27 Mai 201630min

a16z Podcast: Managing Uncertainty -- Layoffs and Talent

a16z Podcast: Managing Uncertainty -- Layoffs and Talent

In many ways, managing startups is about managing uncertainty: in product, market, and... people. So what happens when changes in the business require changes -- and sometimes reductions -- in the workforce? In this episode of the podcast, a16z partners Shannon Schiltz and Alex Rampell share both their professional and personal experiences with layoffs -- from why they happen to what to do (and what not to do).

26 Mai 201629min

a16z Podcast: Automation, Jobs, & the Future of Work (and Income)

a16z Podcast: Automation, Jobs, & the Future of Work (and Income)

There's no question automation is taking over more and more aspects of work and some jobs altogether. But we're now entering a "third era" of automation, one which went from taking over dangerous work to dull work and now decision-making work, too. So what will it take to deal with a world -- and a workplace -- where machines could be thought of as colleagues? The key lies in distinguishing between automation vs. augmentation, argue the guests on this episode of the a16z Podcast, IT management professor Thomas Davenport and Harvard Business editor Julia Kirby, who authored the new book Only Humans Need Apply: Winners and Losers in the Age of Smart Machines. But the argument isn't as simple as saying humans will just do the creative, emotionally intelligent work and that machines will do the rest. The future of work is complex and closely tied to the need for structure, identity, and meaning. Which is also why linking the discussion of things like "universal basic income" to the topic of automation isn't just unnecessary, but depressing and even damaging (or so argue the guests on this episode).

23 Mai 201626min

a16z Podcast: Innovation vs. Invention at Google I/O

a16z Podcast: Innovation vs. Invention at Google I/O

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20 Mai 201626min

a16z Podcast: Airspace as the Next Internet-Like Platform

a16z Podcast: Airspace as the Next Internet-Like Platform

One of the most important lessons of the internet age is what happens when we give people -- including companies, developers, engineers, hobbyists, and yes, even a few bad (or dumb) actors -- a new platform, along with the freedom to innovate on top of it. For example, who could have predicted how profoundly the internet would change our economy, given how it started off as a research project -- one where commercial applications were actually frowned upon in the early days? Now, the U.S. is on the cusp of opening up another such platform for commercial and social innovation: airspace (think drones, the non-military kind). There's so many use cases for drones that we already know about, but what about new business use cases? And then, on the policy front, how do we calculate the risk of innovation on a platform made up of atoms (drones) vs. bits (the internet)? What are the pros and cons of registration? Because even though drones are like flying smartphones controlled by software, they're also hard objects that could fall out of the sky ... or go places where no one could go before, for better or worse. The guests on this episode of the a16z Podcast -- continuing our D.C. and tech/innovation/policy theme -- share their thoughts on safety, privacy, paper airplanes, and what they think are some of the most exciting things now possible in airspace. Joining the conversation are Washington, D.C.-based Mercatus Center tech policy lead Eli Dourado, along with graduate research fellow Samuel Hammond; Airware founder and CEO Jonathan Downey; and SkySafe CEO and co-founder Grant Jordan.

18 Mai 201640min

a16z Podcast: The Cloud and The Public Sector

a16z Podcast: The Cloud and The Public Sector

It almost seems like gospel -- or at least a given -- today for startups to embrace the cloud. Services like AWS have powered an entire generation of startups that can now spin up new applications, new businesses, and new experiments with very little investment in new infrastructure. But what about governments -- both in the U.S. and around the world -- trying to adopt the cloud? How do they approach this widely known (yet still nebulous) concept of THE CLOUD? Especially given sometimes competing considerations around security and compliance with the desire to innovate? Teresa Carlson, Vice President of Worldwide Public Sector for Amazon Web Services, shares tales from the field in this episode of the a16z Podcast -- continuing our on-the-road series from Washington, D.C. Adopting a cloud-based approach is one of the ways to democratize entrepreneurship, but how do countries and governments, not just companies and entrepreneurs, think about this, especially given the tendency towards "balkanization" of the cloud? All this and more in this episode...

17 Mai 201629min

a16z Podcast: The Art of the Regulatory Hack

a16z Podcast: The Art of the Regulatory Hack

If the next 20 years of startup-led tech innovation are going to be about addressing massive problems -- like health, energy, transportation, cities, education, and more -- it will mean more directly confronting (instead of stealthily bypassing) regulatory barriers and incumbent-driven regulatory capture challenges. So how can startups "growth hack" in a highly regulated sector? In this episode of the a16z Podcast -- the second of our podcasts from our most recent on-the-road trip in Washington, D.C. -- Evan Burfield, the co-founder and co-CEO of D.C.-based global incubator 1776, outlines the techniques (really, an art form) of "regulatory hacking". It's not just a way to enter a market, but a way to create a market ... much like Elon Musk did with Tesla: using the very system that drops lemons to make lemonade. The technique begins by understanding informal and formal power; "power mapping" the influencers all across the chessboard (from the top down and bottom up); telling your startup brand/product story in a particular way; and then making your moves. Just as there's a playbook for navigating Silicon Valley, there's one for navigating D.C., argues Burfield; and while many entrepreneurs instinctively just want to get regulations out of the way, sometimes, you just need to know how to play the game.

17 Mai 201634min

a16z Podcast: On Productivity, Immigration, Trump, and Media

a16z Podcast: On Productivity, Immigration, Trump, and Media

Sometimes, our career paths are accidental not intentional... but then it all fits together and makes perfect sense in hindsight. This was especially true for Ezra Klein, who went from writing for his college's alternative paper The Fish Wrap Weekly in the early days, to blogging, and then went to The American Prospect; Washington Post (where he started the very popular policy blog Wonkblog); and now, Vox, where he is the editor-in-chief. All without quite knowing, until after the fact, that he happened to be very interested in policy. In this episode of the a16z Podcast -- the first of our podcasts from our most recent on-the-road trip, this time from Washington, D.C. -- Klein shares his views on tech, policy, and more, including: the productivity (measurement) debate, immigration, the Trump x media phenomenon, and media entrepreneurship overall. Oh and on full-stack startups, too.

12 Mai 201640min

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