The Laura Dowling Experience25 Sep 2025

Healthspan Over Lifespan: Longevity Lessons for People and Pets with Matt Kaeberlein #136

In this episode of the Laura Dowling Experience, Matt Kaeberlein, a global leader in ageing science, discusses his mission to help people and animals live longer and healthier lives by modifying the biological mechanisms of ageing. Matt, CEO of Optisan, a healthcare technology company, talks about his transition from academia to entrepreneurship and highlights the importance of lifestyle factors—nutrition, exercise, sleep, and social connection—in maximising health span. The conversation explores emerging approaches to longevity, including hormone therapy, therapeutic plasma exchange, and the use of drugs such as rapamycin and SGLT2 inhibitors. Matt shares personal experiences with ageing-related health strategies and offers valuable insights into the role of love and altruism in achieving a fulfilling life.

Timestamps

02:48 – Introduction: Meet Matt Kaeberlein, global leader in ageing science

03:13 – What does Matt Kaeberlein do? Biological mechanisms of ageing

04:40 – The concept of health span vs. lifespan

06:55 – Four pillars of health span: Eat, Move, Sleep, Connect

09:04 – The importance of human and animal connection

11:06 – Beyond lifestyle: Hormones and health span

16:06 – Menopause, HRT, and women’s health

24:55 – Testosterone therapy for men: Risks and benefits

31:35 – Alcohol, lifestyle, and longevity

34:34 – Environmental exposures: Heavy metals, microplastics, and health

39:44 – Therapeutic plasma exchange and ageing research

47:09 – Rapamycin: The science, trials, and potential for longevity

59:46 – Diet, fasting, and inflammation: What Matt Kaeberlein eats

1:07:32 – Continuous glucose monitoring and behaviour change

1:14:07 – SGLT2 inhibitors and other promising drugs

1:19:07 – Final advice: Choose love, not fear; the meaning of life

Thanks for listening! You can watch the full episode on YouTube here. Don’t forget to follow The Laura Dowling Experience podcast on Instagram @lauradowlingexperience for updates and more information. You can also follow our host, Laura Dowling, @fabulouspharmacist for more insights and tips. If you enjoyed this episode, please subscribe and leave a review—it really helps us out! Stay tuned for more great conversations.

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