The PREDIMED Trial – Controversy, Criticisms, & Lessons Learned (SNP 22)

The PREDIMED Trial – Controversy, Criticisms, & Lessons Learned (SNP 22)

Links:

About This Episode:

PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.

The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.

But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.

Participants in the PREDIMED trial were randomly assigned to one of three groups:

  • A Mediterranean diet supplemented with extra-virgin olive oil.
  • A Mediterranean diet supplemented with mixed nuts (walnuts, almonds, and hazelnuts).
  • A control group following a low-fat diet.

Despite the issues it still ends up being an incredibly useful source of data.

In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.

Note: This is a Premium-exclusive episode, so in order to listen to the full episode you'll need to subscribe to Sigma Nutrition Premium.

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(643)

#620: BPC-157 and Peptide Medications: What Do We Know? – Jordan Feigenbaum, MD

#620: BPC-157 and Peptide Medications: What Do We Know? – Jordan Feigenbaum, MD

Commonly people are talking about "peptides" to refer to a heterogeneous group of peptide medications or investigational compounds. These are increasingly promoted for injury recovery, tissue repair, ...

15 Sep 57min

#619: How Much Fish Should a Healthy Diet Contain?

#619: How Much Fish Should a Healthy Diet Contain?

Most dietary guidelines recommend eating one to two servings of fish per week, often specifying that at least one serving should be oily fish. But how directly is that recommendation supported by evid...

8 Sep 1h 3min

#618: How Wellness & Optimisation Culture Can Commodify Science – Nick Tiller, PhD

#618: How Wellness & Optimisation Culture Can Commodify Science – Nick Tiller, PhD

Wellness and optimisation culture increasingly presents itself as "science-based". But citing studies, using technical language, or having scientific credentials does not guarantee that the underlying...

1 Sep 56min

#617: What Does Effective Athlete Support Look Like in Practice? – Gemma McGuinness

#617: What Does Effective Athlete Support Look Like in Practice? – Gemma McGuinness

Effective athlete support requires more than delivering technically correct nutrition advice. It depends on understanding the athlete's wider environment, anticipating the pressures that disrupt good ...

25 Aug 46min

Fiber: Independent Benefits or Just a Proxy for Healthy Foods?

Fiber: Independent Benefits or Just a Proxy for Healthy Foods?

This episode answers one of the questions raised in the most recent Q&A episode on Sigma Nutrition Premium.  The full episode includes the following questions: Fiber: Independent effect or proxy for ...

18 Aug 21min

#616: More Testing, Better Health? Harms of Overdiagnosis & Overtreatment - Austin Baraki, MD

#616: More Testing, Better Health? Harms of Overdiagnosis & Overtreatment - Austin Baraki, MD

Medical screening is often framed as an uncomplicated good: if disease is found earlier, treatment can begin earlier and outcomes should improve. This episode examines why that reasoning is incomplete...

11 Aug 1h 15min

#615: Why Processing Doesn't Determine the Healthfulness of Plant-Based Diets – Alysha Thompson, PhD

#615: Why Processing Doesn't Determine the Healthfulness of Plant-Based Diets – Alysha Thompson, PhD

What does the evidence actually show when we look at plant-based dietary patterns through the lens of food processing? And does classifying foods as "ultra-processed" meaningfully change how we interp...

4 Aug 56min

#614: The Human Skills of Nutrition Coaching – Krista Scott-Dixon, PhD

#614: The Human Skills of Nutrition Coaching – Krista Scott-Dixon, PhD

In nutrition and health coaching, one of the central challenges is understanding how people actually change, particularly when life is complex, motivation fluctuates, and behaviour is shaped by emotio...

21 Jul 56min

Populært innen Helse

fastlegen
rss-gukild-johaug
psykodrama
hvordan-har-du-det-mann
leger-om-livet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
rss-skravla-gar
lydartikler-fra-aftenposten
foreldreradet
g-punktet
morten-ramm-lar-kakla-ga-til-du-sovner
klimaks
rss-lopedrommen
treningsprat
bak-fasaden-en-reise-i-livet-med-sykepleier-ine
rss-dagen-for-dagen
hjernesterk
rss-kunsten-a-leve
rss-loping-for-nybegynnere
hverdagspsyken