The Lead Podcast presented by Heart Rhythm Society16 Okt 2025

The Lead Episode 123: A Discussion of Re-Ablation of Atrial Fibrillation Targeting Electrogram Dispersion –The RESTART Trial, Live at HRX 2025

Join host and HRS Digital Education Committee Vice-Chair, Tina Baykaner, MD, MPH and her guests Jerome Kalifa, MD and Paul C. Zei, MD, PhD, FHRS as they discuss this article at HRX 2025 in Atlanta.

The RESTART trial is an international, multicenter, non-randomized interventional study designed to assess whether using Volta Medical's AI-assisted algorithm to identify and ablate dispersed electrograms (EGMs) in addition to doing repeat pulmonary vein isolation can improve outcomes in patients whose atrial fibrillation recurred after previous ablations.The main goal is to see the proportion of patients who are free from AF twelve months after the repeat procedure (without antiarrhythmic drugs), and the trial contains about 92 patients.

Learning Objective

Describe the design and purpose of the RESTART trial, including how the use of AI-guided identification and ablation of dispersed electrograms aims to improve outcomes for patients undergoing repeat ablation for recurrent atrial fibrillation.

Article Authors

John D. Hummel
Haroon Rachid
Isabel Deisenhofer
Paul C. Zei
Gustavo Morales
Jerome Horvilleur
Stavros Mountantonakis
Jean-Paul Albenque
Devi G. Nair
Benjamin D'Souza
Smit C. Vasaiwala
Tom De Potter
Daniel H. Cooper
Mark Metzl
Adi Lador
Anthony R. Magnano
Alexandru B. Chicos
Joshua R. Silverstein
Daniel Guerrero
Shirley Beguin
Anas El-Benna
Sabine Lotteau
Marie-Sophie Nguyen-Tu
Paola Milpied
Jerome Kalifa
Bradley P. Knight
Dhanunjaya R. Lakkireddy

Podcast Contributors

Jerome Kalifa, MD
Paul C. Zei, MD, PhD, FHRS
Tina Baykaner, MD, MPH

All relevant financial relationships have been mitigated.

Host Disclosure(s):

T. Baykaner
•Honoraria/Speaking/Consulting: Volta Medical, Medtronic, Pacemate, Johnson and Johnson, Abbot Medical, Boston Scientific

•Research: NIH

Contributor Disclosure(s):

J. Kalifa:

•Stock Options, Privately Held: Volta Medical

P. Zei
•Research: Biosense Webster, Inc.

•Speaking/Teaching/Consulting: Biosense Webster, Inc., Varian Medical Systems, Abbott

Staff Disclosure(s) (note: HRS staff are NOT in control of educational content. Disclosures are provided solely for full transparency to the learner):

S. Sailor: No relevant financial relationships with ineligible companies to disclose.

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