Orphan Drugs
99% Invisible14 Nov 2018

Orphan Drugs

We chronicle the epic struggle to get drugs that treat very rare diseases on the market, and the unintended consequence of that fight, which affected the cost of all kinds of drugs. This is a strange story that involves a hit 70s TV show, a fake march on Washington, a courageous advocate, a carnival concessions wholesaler, and a new drug law that helped a lot of people, made drug companies billions of dollars, and opened a whole can of worms.

Adapted from the new podcast An Arm and a Leg by Dan Weissmann

Orphan Drugs

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A Sea Worth its Salt

A Sea Worth its Salt

The largest body of water in California was formed by a mistake. In 1905, the California Development Company accidentally flooded a huge depression in the Sonora Desert, creating an enormous salty lake called the Salton Sea. The water is about … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

9 Aug 201617min

The Magic Bureaucrat

The Magic Bureaucrat

In 1996, President Bill Clinton and the Congress undertook a reform effort to redesign the welfare system from one that many believed trapped people in a cycle of dependence, to one, that in the President’s words, would give people “a … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

3 Aug 201632min

Combat Hearing Loss

Combat Hearing Loss

The US military buys a lot of foam ear plugs. Visit any base and you’ll find them under the bleachers at the firing range, in the bottoms of washing machines. They are cheap and effective at making noise less … noisy. … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

26 Juli 201616min

America’s Last Top Model

America’s Last Top Model

In 1943, the Army Corps of Engineers began construction on a scale model that could test flooding in all 1.25 million square miles of the Mississippi River. It would be a three-dimensional map of nearly half of the continental United … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

19 Juli 201619min

The Mind of an Architect

The Mind of an Architect

In the late 1950s, the Institute of Personality Assessment and Research embarked on a mission to study the personalities of particularly creative scientists and artists. Researchers established categories, grouping analytical creatives together (including scientists and mathematicians) as well as artistic … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

13 Juli 201621min

Unpleasant Design

Unpleasant Design

Benches in parks, train stations, bus shelters and other public places are meant to offer seating, but only for a limited duration. Many elements of such seats are subtly or overtly restrictive. Arm rests, for instance, indeed provide spaces to rest arms, but they … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

6 Juli 201613min

Remembering Stonewall

Remembering Stonewall

It started with a place called the Stonewall Inn. Gay bars had been raided by police for decades. Gay, lesbian, bisexual, and transgender people had been routinely arrested and subjected to harassment and beatings by the people who were meant … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

29 Juni 201626min

Home on Lagrange

Home on Lagrange

In 1968, an Italian industrialist and a Scottish scientist started a club to address what they considered to be humankind’s greatest problems—issues like pollution, resource scarcity, and overpopulation. Meeting in Rome, Italy, the group came to be known as the … Continue reading → Subscribe to SiriusXM Podcasts+ to listen to new episodes of 99% Invisible ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus.

22 Juni 201626min

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