253: Nap1 and histone acetylation tune chromatin condensates
Gao J et al., Nature Communications - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and the histone chaperone Nap1 increase intern...
8 Jan 20min
252: Keratinocytes to cSCC: genetic steps
Deivendran D et al., Nature Communications, doi:10.1038/s41467-025-65687-y - Single-cell and spatial multi-omic profiling maps the genetic and transcriptional changes from normal keratinocytes through...
7 Jan 18min
251: MuSCs, laminin-α2 and LAMA2 MD
McGowan TJ et al., Nature Communications, doi:10.1038/s41467-025-65703-1 - Activated muscle stem cells express and secrete laminin-α2 to remodel their niche, and loss of MuSC-derived laminin-α2 slows ...
6 Jan 19min
250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ
Nieminuszczy J et al., Nature Communications, doi:10.1038/s41467-025-65594-2 - This study shows the CIP2A-TOPBP1 complex coordinates two mitotic double-strand break repair pathways, MiDAS and MMEJ, by...
5 Jan 18min
249: PCM1 links centrosome asymmetry to endosome dynamics
Zhao X et al., Nature Communications - In developing neural progenitors PCM1 localizes to the mother centrosome and to Notch ligand-containing endosomes, promoting Par-3/dynein assembly and Rab5-to-Ra...
4 Jan 20min
248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation
Kutchukian C et al., Nature Communications - Disruption of the PIKfyve/Fig4/Vac14 complex drives ULK1-dependent trafficking of PI4KIIα and ATG9A to lysosomes, elevating lysosomal PI(4)P to promote mem...
3 Jan 21min
247: Genome graphs reveal structural variation in M. tuberculosis
Canalda-Baltrons A et al., Nature Communications - Long-read assemblies and a pangenome reference graph uncover widespread structural variants that shape Mycobacterium tuberculosis evolution and contr...
2 Jan 21min
246: SV2A structural pharmacology and allosteric occlusion
Pidathala S et al., Nature Communications - High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a secondary allosteric pocket modul...
1 Jan 16min
