245: Benchmarking DNA foundation models
Feng H et al., Nat Commun - A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean token embeddings improve classification and that...
31 Dec 202519min
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
Sun Z et al., Nature Communications - Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects...
30 Dec 202517min
243: Genome-wide UVB GxE study finds 162 vitamin D variants
Shraim R et al., Nat Commun - A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including...
29 Dec 202517min
242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats
Godin P et al., Nature Communications - A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced sustained supraphysiological...
28 Dec 202517min
241: Wagyu T2T reveals a cattle X neocentromere
Pineda PS et al., Nature Communications - A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and transposable element expansion, adds hun...
27 Dec 202518min
240: CYFIP1 controls cortical axon development by modulating calcium
Ricci C et al., Nature Communications - Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function. Key terms: cyfip1, axon...
26 Dec 202518min
239: Genomic Adaptations of the Svalbard Reindeer
Genome Biology and Evolution - The Genomic Basis of the Svalbard Reindeer’s Adaptation to an Extreme Arctic Environment Music:Enjoy the music based on this article at the end of the episode. Article...
25 Dec 202519min
238: Germline polymorphisms shape antibody light chain repertoires
Engelbrecht E et al., Nat Commun - Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usa...
24 Dec 202518min
