370: ICMT and INPP5E enable BRAFV600E tumor growth
Yang X et al., Proceedings of the National Academy of Sciences - Genetic and pharmacologic inhibition of ICMT suppresses proliferation, invasion, and tumor growth in BRAFV600E-driven models and identi...
18 Mai 23min
369: NEK2 drives EBV-positive NHL pathogenesis
White MC et al., PNAS - This episode reviews a PNAS study showing that the kinase NEK2 is upregulated by EBV and its latency proteins and that NEK2 inhibition with the irreversible inhibitor JH295 sel...
16 Mai 24min
368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model
Jhaldiyal A et al., PNAS - This episode summarizes a PNAS study showing that PARP1 activation links Aβ1-42 toxicity to DNA damage, amyloid accumulation, neuroinflammation, and cognitive deficits, and ...
16 Mai 26min
367: Ancestral Splice Variation Fuels Cichlid Jaw Diversification
Singh P et al., PNAS - This paper compares alternative splicing (AS) and gene expression (GE) across 200 transcriptomes from oral and pharyngeal jaws of 18 haplochromine cichlid species across Lakes V...
15 Mai 22min
366: BRCA1P1 suppresses antiviral and antitumor immunity
Han YJ et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study showing that the BRCA1 pseudogene BRCA1P1 produces circular RNAs that suppress antiviral inna...
15 Mai 24min
365: MEN1 mutations and menin inhibitor resistance
Bourgeois et al., Nature Communications - This study used enhanced CRISPR base editor screens, structural biology, biochemical assays, and in vitro/in vivo selection to map MEN1 mutations that drive r...
15 Mai 22min
364: Peripheral C4 and Schizophrenia: A Neutrophil Gene–Protein Link
Kalinowski A et al., PNAS - This study reports that C4 protein is enriched in human neutrophils and monocytes and that neutrophil C4 protein levels correlate with C4A gene copy number specifically in ...
11 Mai 17min
363: cfDNA size deconvolution reveals a 159‑bp nucleosomal pivot and tumor fragmentomic signatures
Zhou Z et al., Nature Communications - This study develops a Lorentzian deconvolution model of cfDNA fragment length distributions across bodily fluids, identifies a ~159 bp component that demarcates ...
9 Mai 22min
