362: D614G Reshapes Spike Allostery and Speeds RBD Opening
Kearns FL et al., PNAS - Simulations and HDXMS reveal how the D614G substitution alters internal communication in SARS-CoV-2 spike, enabling faster receptor-binding-domain opening through newly engage...
9 Mai 18min
361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs
Beckner RL et al., PNAS - This episode examines a PNAS study using Chiral Inversion Mutagenesis (ChIM) to scan low-complexity domains (LCDs) of Emerin and neurofilament light chain (NEFL). Targeted L-...
8 Mai 24min
360: An inverse correlation between structural linguistic and human genetic diversity
Graff A et al., PNAS - A PNAS study linking global population-genetic data and structural linguistic features finds an inverse correlation: regions with lower genetic diversity show higher structural ...
7 Mai 26min
359: Ultrapotent PDCoV Miniprotein MB11
Avery NG et al., PNAS - This episode covers a PNAS study reporting the de novo design of miniprotein inhibitors targeting porcine deltacoronavirus (PDCoV). The lead minibinder, MB11, binds the PDCoV R...
6 Mai 23min
358: CHCHD4 and a Pediatric OXPHOS Collapse
Mantecon M et al., Human Genetics and Genomics Advances - This episode reviews a brief communication reporting a pediatric patient with biallelic CHCHD4 variants who presented with severe neurological...
5 Mai 25min
356: Recessive Coding Associations Across Six Biobanks
Lassen F et al., The American Journal of Human Genetics - Meta-analysis of up to 948,690 exome- or whole-genome-sequenced individuals across six biobanks used statistical phasing to infer compound-het...
3 Mai 22min
355: Influenza D replicates in the human airway — zoonotic risk
Sanders CG et al et al., PNAS - Surveillance-derived influenza D virus (IDV) isolates were tested across cell lines, primary airway cultures, and precision-cut lung slices to assess human compatibilit...
3 Mai 24min
354: How Cohesin Acetylation and ATPase Shape Chromatin Loops and Cohesion
Costantino L et al., PNAS - Costantino et al. dissect how Eco1-mediated acetylation of Smc3 (K112, K113) and cohesin ATPase activity separately regulate chromatin loop size, loop positioning, and sist...
30 Apr 14min
