268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment
Cail RC et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2521561122 - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts the super-relaxed state and...
23 Jan 22min
267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange
Englander SW et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2520855122 - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct base-pair opening modes: single-base microsecond openi...
22 Jan 21min
266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks
Vatsa A et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2526296123 - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral transcription and replication, act...
21 Jan 17min
265: ANTSR lncRNA and the conserved multiallelic sex-determining locus across Aculeata
Yu C et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2522417123 - Genetic mapping and comparative genomics show the lncRNA ANTSR multiallelic locus in Aculeata directs female development via heterozyg...
20 Jan 17min
264: Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver
Sengstack J et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2515183123 - TRDP with Perturb-seq in human fibroblasts found that manipulating TFs (EZH2, E2F3, STAT3, ZFX) reversed aging hallmarks, and E...
19 Jan 19min
263: Bifacial γPNA triplets target rCUG repeats and displace MBNL1 in Myotonic Dystrophy type 1
Perera J et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2507065123 - Gamma-PNA triplet ligands with Janus bases selectively bind expanded rCUG repeats, displace MBNL1, and show length-dependent coope...
18 Jan 20min
262: Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance)
Strobl et al., Nature Communications - Human epidermal Langerhans cells exposed to Ixodes ricinus tick saliva and Borrelia burgdorferi adopt a tolerogenic state with CXCR4/CCR7-driven emigration that ...
17 Jan 21min
261: MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping
Girelli et al., Nature Communications - MHz-XPCS of ferritin solutions at EuXFEL shows anomalous, cage-trapped protein diffusion with reduced long-time transport and ~1.2 nm rattling at high concentra...
16 Jan 16min
