260: TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics
Nature Communications - Transcription start sites experience a high influx of heritable variants fueled by early development Music:Enjoy the music based on this article at the end of the episode. Ar...
15 Jan 16min
259: Ku filaments that hold DNA together
Zahid S et al., Nature Communications, doi:10.1038/s41467-025-65609-y - Cryo-EM and biophysical analyses show Mycobacterium tuberculosis Ku assembles into DNA-bound oligomeric filaments that synapse D...
14 Jan 17min
258: Correcting GC bias in metagenomes
Holcik L et al., Nature Communications, doi:10.1038/s41467-025-65530-4 - GuaCAMOLE is an alignment-free algorithm that estimates and removes genomic GC-content-dependent sequencing bias to produce mor...
13 Jan 17min
257: PSMC5: proteasomes, immunity and neurodevelopment
Küry S et al., Nature Communications, doi:10.1038/s41467-025-65556-8 - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs proteasome function, d...
12 Jan 18min
256: Compartmental control of VSG silencing
Antunes et al., Nature Communications - The study shows that spatial segregation of core and subtelomeric chromosome compartments, demarcated by protein-rich boundaries and controlled by a phosphoinos...
11 Jan 18min
255: Lipids, Ions and the AE1 Elevator
Chen T et al., Nature Communications - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface and inhibit the OF⇌IF conformational transition w...
10 Jan 19min
254: Rescuing the replisome at a nick
Winterhalter et al., Nature Communications - Cas9 nickases in Bacillus subtilis show that single-strand nicks in either template strand arrest DNA replication, create single-end double-strand breaks, ...
9 Jan 19min
253: Nap1 and histone acetylation tune chromatin condensates
Gao J et al., Nature Communications - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and the histone chaperone Nap1 increase intern...
8 Jan 20min
