263: Bifacial γPNA triplets target rCUG repeats and displace MBNL1 in Myotonic Dystrophy type 1
Perera J et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2507065123 - Gamma-PNA triplet ligands with Janus bases selectively bind expanded rCUG repeats, displace MBNL1, and show length-dependent coope...
18 Jan 20min
262: Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance)
Strobl et al., Nature Communications - Human epidermal Langerhans cells exposed to Ixodes ricinus tick saliva and Borrelia burgdorferi adopt a tolerogenic state with CXCR4/CCR7-driven emigration that ...
17 Jan 21min
261: MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping
Girelli et al., Nature Communications - MHz-XPCS of ferritin solutions at EuXFEL shows anomalous, cage-trapped protein diffusion with reduced long-time transport and ~1.2 nm rattling at high concentra...
16 Jan 16min
260: TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics
Nature Communications - Transcription start sites experience a high influx of heritable variants fueled by early development Music:Enjoy the music based on this article at the end of the episode. Ar...
15 Jan 16min
259: Ku filaments that hold DNA together
Zahid S et al., Nature Communications, doi:10.1038/s41467-025-65609-y - Cryo-EM and biophysical analyses show Mycobacterium tuberculosis Ku assembles into DNA-bound oligomeric filaments that synapse D...
14 Jan 17min
258: Correcting GC bias in metagenomes
Holcik L et al., Nature Communications, doi:10.1038/s41467-025-65530-4 - GuaCAMOLE is an alignment-free algorithm that estimates and removes genomic GC-content-dependent sequencing bias to produce mor...
13 Jan 17min
257: PSMC5: proteasomes, immunity and neurodevelopment
Küry S et al., Nature Communications, doi:10.1038/s41467-025-65556-8 - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs proteasome function, d...
12 Jan 18min
256: Compartmental control of VSG silencing
Antunes et al., Nature Communications - The study shows that spatial segregation of core and subtelomeric chromosome compartments, demarcated by protein-rich boundaries and controlled by a phosphoinos...
11 Jan 18min
