236: XPD translocation and genetic disease etiology
Paul T et al., Nat Commun - Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disru...
22 Des 202519min
235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
Sands et al., Nature Communications - Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal random monoallelic...
21 Des 202517min
234: MTHFR genotype and methionine metabolism predict COVID-19 severity
Petrova B et al., Proc Natl Acad Sci U S A - IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism together with MTHFR C677T genotype at hosp...
20 Des 202520min
233: NuA3 structure reveals the mechanism of H3K14 acetylation
Shi W et al., Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex - Cryo-EM structures of the yeast NuA3 complex show a composite histone ...
19 Des 202518min
232: Lamin A/C steers fork restart via H3K9me3 and PARylation
Cherdyntseva V et al., Nat Commun - Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting local H3K9me3 and ADP-ribosylatio...
18 Des 202517min
231: Transcription start sites as a germline mutational hotspot
Cortés Guzmán M et al., Nat Commun - This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in part by early embryonic mosaic variants and t...
17 Des 202517min
230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
Sirvydis K et al., Nat Commun - A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1 deacetylase activity and causing a multisystem neu...
17 Des 202518min
229: Inhibiting PCBP2 condensates in Alzheimer’s
Wang L et al., Nat Commun - Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small mole...
15 Des 202519min
