Base by Base

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(444)

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

StealTHY CRISPR: Revealing Hidden Metastasis Regulators Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License (CC BY 4.0) Support:Base by Ba...

20 Nov 202516min

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Divergent Evolutionary Dynamics of Benign and Malignant Tumors Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article publishe...

19 Nov 202518min

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License (CC BY 4.0) Support:Base by B...

19 Nov 202517min

201: Sex, Smoking, and Somatic Selection in the Bladder

201: Sex, Smoking, and Somatic Selection in the Bladder

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09521-x License:This episode is based on an open-access article published under the Creative Commons Att...

17 Nov 202514min

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09448-3 License:This episode is based on an open-access article published under the Creative Commons Att...

16 Nov 202518min

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article p...

15 Nov 202513min

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article pu...

14 Nov 202515min

197: Somatic Mutation and Selection at Population Scale

197: Somatic Mutation and Selection at Population Scale

Somatic Mutation and Selection at Population Scale Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under the ...

13 Nov 202515min

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