Base by Base
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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(444)

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Impact of Chromatin Accessibility QTLs Across Immune Contexts Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published...

12 Nov 202516min

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no sponsors, no paywall. If an episode was worth your time, chip in and keep t...

11 Nov 202518min

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we explore how Bayesian reasoning can be used to reconstruct the famous...

10 Nov 202514min

193: SARM1, DNA, and the Death Signal

193: SARM1, DNA, and the Death Signal

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts as a double-stranded DNA sensor that triggers NAD+ loss...

9 Nov 202515min

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin contacts reveal a unifi...

8 Nov 202514min

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore a Nature Communications study that proposes CATphis...

7 Nov 202519min

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

Martínez‑López JA et al et al., Nature Communications - This episode examines a Nature Communications study that introduces differential Gene Coordination Network Analysis (dGCNA) applied to deep Smar...

6 Nov 202515min

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how genome-wide DNA methylation profiling can p...

5 Nov 202514min

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