Base by Base

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(444)

164: m6A in the coding sequence: linking deposition, translation, and decay

164: m6A in the coding sequence: linking deposition, translation, and decay

Ćorović M et al., Trends in Genetics - m6A in the coding sequence: linking deposition, translation, and decay Music:Enjoy the music based on this article at the end of the episode. Article title:m6A...

11 Okt 202514min

163: Animal origins: looping back in time

163: Animal origins: looping back in time

Matar O et al., Trends in Genetics - Animal origins: looping back in time Music:Enjoy the music based on this article at the end of the episode. Article title:Animal origins: looping back in time F...

10 Okt 202514min

162: Spatial miRNomics: technologies, challenges, and opportunities

162: Spatial miRNomics: technologies, challenges, and opportunities

Robles-Remacho A et al., Trends in Genetics - A concise review of emerging methods to map microRNA (miRNA) expression in tissues with spatial context, covering imaging and sequencing approaches, techn...

9 Okt 202520min

161: Decoding genomic landscapes of introgression

161: Decoding genomic landscapes of introgression

Huang X et al., Trends in Genetics - A concise review of methodological advances for identifying introgressed loci across genomes. The article surveys summary statistics, probabilistic modeling, and s...

8 Okt 202520min

160: Long reads meet single-cell omics

160: Long reads meet single-cell omics

Wen L et al., Trends in Genetics - This review surveys the integration of single-molecule long-read sequencing (SMS) with single-cell genomics, epigenomics and transcriptomics, describing platforms, m...

7 Okt 202515min

159: Short Reads, Big Biodiversity: The Untapped Potential of Genome Skimming

159: Short Reads, Big Biodiversity: The Untapped Potential of Genome Skimming

Bleidorn C et al., Trends in Genetics - This episode examines a Trends in Genetics review arguing that short-read shotgun sequencing and genome skimming remain powerful, cost-effective tools for biodi...

6 Okt 202515min

158: Interruptions in repeat expansion diseases and the SD-MMEJ hypothesis

158: Interruptions in repeat expansion diseases and the SD-MMEJ hypothesis

Aston AN et al., Trends in Genetics - This opinion article reviews how short sequence interruptions within expanded tandem repeats alter somatic instability and clinical outcomes across multiple repea...

5 Okt 202522min

157: Synthetic Gametes and the Non-Identity Problem

157: Synthetic Gametes and the Non-Identity Problem

Villalba A et al., Trends in Genetics - A concise exploration of how synthetic DNA could enable engineered haploid gametes, why that possibility intensifies the philosophical non-identity problem, and...

4 Okt 202514min

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