Base by Base

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(463)

175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk

175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk

️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how enhancer–promoter 3D chromatin maps from five primary ...

22 Okt 202519min

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore a PNAS study revealing how TMEM217 forms a complex wi...

21 Okt 202516min

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS study showing how a synthetic bottlebrush block copolyme...

20 Okt 202520min

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS study showing that short, previously nongenic DNA sequ...

19 Okt 202519min

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Danchuk S et al., Proceedings of the National Academy of Sciences - Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? Music:Enjoy the music based on this article at...

18 Okt 202516min

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Picchetta L et al., The American Journal of Human Genetics - Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans Music:Enjoy the music based on this article at the end of the episode...

17 Okt 202517min

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Aslanzadeh V et al., Nature Communications - Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance Music:Enjoy the music based on this article at the end of...

16 Okt 202521min

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Baird D et al., Nature Communications - Low circulating miR-190a-5p predicts progression of chronic kidney disease Music:Enjoy the music based on this article at the end of the episode. Article titl...

15 Okt 202519min

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