132: Transcriptome classifiers predict docetaxel sensitivity in advanced prostate cancer
Grist E et al., Cell - Large-scale transcriptome profiling of 1,523 diagnostic prostate tumors from randomized STAMPEDE phase 3 trials linked expression signatures and immunohistochemistry to 14-year ...
9 Sep 202520min
131: Cryptic plasmid pBI143: a small element with outsized presence in the human gut
Fogarty EC et al., Cell (187:1206–1222, February 29, 2024) - This episode summarizes Fogarty et al. 2024, which characterizes pBI143, a 2.7 kb cryptic plasmid that is highly prevalent and abundant acr...
8 Sep 202517min
130: Genetics + CRISPR to Map Obesity and Fat Distribution
Baya NA et al., The American Journal of Human Genetics - This episode summarizes a multi-modal study that integrates exome sequencing in 402,375 UK Biobank participants with CRISPR knockdown in human ...
7 Sep 202520min
129: NPIP — Structural variation, selection, and paralog diversification
Dishuck PC et al., Cell Genomics - Using 169 long-read human haplotypes and 1.4 billion full-length cDNA reads, Dishuck et al. resolve the complex NPIP gene family on chromosome 16, revealing extreme ...
6 Sep 202522min
128: L1 elements, chromatin and CRISPRi
Adami A et al., Cell Genomics - This episode covers analyses of L1 retrotransposon subfamilies (L1PA2/3/4, L1HS), their chromatin signatures (including H3K4me3), and perturbation experiments using CRI...
5 Sep 202515min
127: OncoGAN: Generating Synthetic Cancer Genomes with AI
Díaz-Navarro A et al., Cell Genomics - OncoGAN is a multimodel generative AI pipeline that simulates realistic, privacy-preserving cancer genomes (VCFs, CNAs, SVs) across eight tumor types to support ...
4 Sep 202517min
126: Smith-Magenis Syndrome: Chromatin Rewiring to Hyperexcitable Neurons
Lee Y et al., The American Journal of Human Genetics - This episode reviews a study using hiPSC-derived 2D cortical neurons and 3D cortical organoids from individuals with del(17)p11.2 (Smith-Magenis ...
3 Sep 202520min
125: GP2: A Global Roadmap for Parkinson’s Genetics
Blauwendraat C et al., The American Journal of Human Genetics - This episode reviews a perspective on the Global Parkinson’s Genetics Program (GP2), a coordinated international effort to expand Parkin...
2 Sep 202522min
