44: Polε Proofreading Revealed
Wang F et al., PNAS - This episode examines a cryo-EM study that captures authentic proofreading intermediates of human Polε in complex with PCNA by generating a mismatch in situ. The work reveals how...
12 Jun 202519min
43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping
Kjærgaard J et al., Cell - This episode reviews a study that links in vivo insulin sensitivity phenotyping with proteome and signaling-pathway mapping to define molecular-phenotype associations across...
11 Jun 202519min
42: Amino acids catalyse RNA formation under ambient alkaline conditions
Rout SK et al., Nature Communications - A Nature Communications study shows that proteinogenic amino acids accelerate non-enzymatic RNA oligomerisation from ribonucleoside-2',3'-cyclic phosphates unde...
11 Jun 202523min
41: Valuing Genomic Newborn Screening: Australian Public Preferences
Peters R et al., The American Journal of Human Genetics - This episode reviews a nationwide survey of 2,509 Australian adults using two discrete choice experiments to quantify public preferences and t...
10 Jun 202518min
40: Lysosomal SLC7A11 and acidification
Provided PDF (truncated source text) et al., Cell - This episode reviews a study that examines SLC7A11 (7A11) localization to lysosomes and its impact on lysosomal acidification, cystine/cysteine bala...
9 Jun 202517min
39: Scaling whole-genome polygenic scores with VIPRS
Zabad S et al., The American Journal of Human Genetics - This episode covers Zabad et al.'s methods to scale summary-statistics-based polygenic risk score (PRS) inference to millions of variants. The ...
7 Jun 202519min
38: Bat ancestors, recombination, and rapid travel: origins of SARS-CoV and SARS-CoV-2
Pekar JE et al., Cell - Recombination-aware, whole-genome analyses of sarbecoviruses show that genomic fragments very closely related to SARS-CoV and SARS-CoV-2 circulated in horseshoe bats only years...
7 Jun 202520min
37: Prioritizing missense variants with chemoproteomic-detected amino acids
Palafox MF et al., The American Journal of Human Genetics - This episode explores a multi-omic study showing that mass spectrometry–based chemoproteomic detection of cysteine, lysine, and tyrosine (Cp...
6 Jun 202523min
