386: Genome Doubling and the Bioeconomy
Peeters MKR et al., Proceedings of the National Academy of Sciences (PNAS) - A perspective outlining how genome doubling (polyploidy) reshapes genomes, phenotypes, and ecological interactions and how ...
5 Jun 24min
385: Growth under Pressure: Polyploidy Induced by Stress
Sarabia Olivera L et al., PNAS - A perspective that surveys how diverse stresses trigger whole‑genome doubling (polyploidy) across fungi, plants, and animals, outlines common cell‑cycle mechanisms tha...
4 Jun 24min
384: RNA Brake on Cholera Phage: CisR Controls CTXϕ
Haycocks JRJ et al., PNAS - This episode examines the discovery of CisR, a small RNA produced from the 3’UTR of prtV in Vibrio cholerae, which posttranscriptionally represses the CTXϕ-encoded cep mRNA...
3 Jun 23min
383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links
Koprulu M et al., Cell - A 38-cohort proteogenomic meta-analysis of up to 78,664 people maps fine‑mapped protein quantitative trait loci (pQTLs) across 1,116 circulating proteins, uses machine learnin...
2 Jun 23min
382: How animal blood cells evolved from unicellular ancestors
Nagahata Y et al., PNAS - A transcriptome-driven reconstruction of blood cell evolution shows modern animal blood lineages arose by repurposing an ancestral unicellular toolkit. The study traces macro...
2 Jun 26min
381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)
Battistoni G et al., PNAS - This paper presents BALI, a light-driven method that writes combinatorial DNA spatial barcodes directly onto biomolecules in tissue by iterative photocleavage and ligation,...
1 Jun 26min
380: Prime-SGE maps drug-resistance variants at scale
Abadie FMC et al., Cell Genomics - Abadie et al. present prime‑SGE, a pooled prime‑editing framework that installs thousands of precise point mutations across multiple oncogenes and identifies drug‑re...
29 Mai 11min
379: Long reads reveal hidden structural and repeat variation in autism
Mortazavi M et al., Cell Genomics - PaperCast Base by Base discusses a long-read whole-genome sequencing study of 267 individuals from 63 families that increased detection of structural variants and t...
27 Mai 26min
