394: Benchmarking LLMs for cfRNA biomarker discovery
Gaudio HA et al., Nature Communications - This episode examines a systematic benchmark of six commercial large language models applied to plasma cell-free RNA across three clinical cohorts, assessing ...
17 Jun 22min
393: Hidden Resistance: tNGS Reveals Rifampicin and Bedaquiline Resistance in Eswatini
Vambe D et al., Nature Communications - This study reports the programmatic introduction of targeted next-generation sequencing (tNGS) in Eswatini and shows that tNGS detected large amounts of rifampi...
17 Jun 21min
392: GWAS of Cocaine Self-Administration in Heterogeneous Stock Rats
Lara MK et al et al., Nature Communications - Large GWAS in 836 outbred HS rats identifies six loci linked to cocaine self-administration traits, highlighting Ces1 carboxylesterase genes and other loc...
12 Jun 23min
391: The Kaufmann Protocol — Why We Age and How to Stop It
Dr. Sandra Kaufmann, The Kaufmann Anti-Aging Institute - Dr. Sandra Kaufmann — physician, scientist and athlete — set out to understand aging and fight it with science. This episode is a guided overvi...
12 Jun 1h 6min
390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense
Gätgens C et al., PNAS - This episode examines how DNA-intercalating molecules like daunorubicin block bacteriophage infection at an early stage, causing an abortive-infection-like outcome via toxic p...
9 Jun 22min
389: Crotonylation impedes c-Myc oncogenic activity
PNAS - This study identifies crotonylation as a posttranslational modification of c-Myc that reduces its transcriptional and oncogenic activity. Key lysines K289 and K298 are crotonylated; loss of cro...
9 Jun 25min
388: Base by Base | Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis
Huang X et al., Proceedings of the National Academy of Sciences (PNAS) - This episode summarizes a PNAS study reporting CD163‑targeted lipid nanoparticles that deliver FAP‑specific CAR mRNA to liver m...
9 Jun 21min
387: Homotypic Dengue Reinfections and Long-Term Antibody Decay
Andrade J et al., PNAS - Analysis of three long-term cohorts in the Philippines and Thailand shows antibody titers wane over years and that homotypic dengue reinfections are common and required to exp...
9 Jun 21min
