Matching Drugs to Genetic Abnormalities to Precisely Treat Cystic Fibrosis
Cystic fibrosis is a common autosomal recessive disease. It is caused by any one of many discrete genetic abnormalities that affect chloride transport. Identification of specific genetic abnormalities...
5 Des 201726min
Mendelian Randomization: How the Natural Assortment of Genes Can Mimic Randomized Clinical Trials
The best evidence for proving cause-and-effect comes from randomized clinical trials. However, they are expensive and difficult to perform. The natural assortment of gene variants at birth can mimic r...
21 Nov 201729min
Bacteriophage Treatment for Serious Infections Is Back!
Bacteriophages are viruses that infect and kill bacteria. When they were first discovered in the early part of the 20th century, there was great enthusiasm for their potential use to treat all sorts o...
14 Nov 201737min
Incontinence in Women: How We Talk About It and What Can Be Done
Urinary incontinence in women is common but not often discussed. Linda Brubaker, MD, and Emily S. Lukacz, MD, review the evaluation and management of incontinence in women, including how to broach the...
24 Okt 201733min
Managing Transgender Patients: Endocrine Society Guideline Update 2017
An increasing number of transgender patients are being seen in all care settings. Their medical needs are not too different from those for any primary care patient. New guidelines issued by the Endocr...
17 Okt 201725min
Replacing Tissue Biopsies With a Blood Test: The Technique of Liquid Biopsy
Powerful new genetic technologies enable clinicians to detect and sequence tiny amounts of free DNA circulating in blood. DNA gets into blood when cells fall apart. Abnormal DNA from diseased cells ca...
3 Okt 201726min
Delirium: Prevention, Diagnosis, and Treatment
Delirium goes unrecognized in approximately 60% of cases. When it is recognized, it can be difficult to treat. Recognizing and treating, as well as preventing, delirium is important because delirium i...
26 Sep 201723min
Breast Cancer Surgery: Less Is More
Every successive major clinical trial of less invasive breast cancer surgery seems to show that less is more--less because less surgery seems to not influence outcomes and more because with less surge...
12 Sep 201734min
