229: Inhibiting PCBP2 condensates in Alzheimer’s
Wang L et al., Nat Commun - Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small mole...
15 Dec 202519min
228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
Gopal AB et al., Nat Commun - Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antige...
14 Dec 202518min
227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
Couvreu de Deckersberg E et al., Nat Commun (2025) - This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with ch...
13 Dec 202516min
226: FGF4 protects podocytes in diabetic kidney disease
Wang S et al., Nat Commun - This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMP...
12 Dec 202516min
225: VRK-1, BAF-1 and the release of meiotic chromatin
Paouneskou D et al., Nature Communications - VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pai...
10 Dec 202517min
224: Biohybrid implants: wireless sensing with engineered bacteria
Bilir A et al., Wireless in-body sensing through genetically engineered bacteria - A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by contr...
10 Dec 202518min
223: Torsion Controls Replication: Stall and Restart
Xiaomeng Jia et al., Berger, Smita S - New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation. Key terms: DNA replication, tor...
9 Dec 202516min
222: snaR-A disrupts mRNA splicing in cancer
Zhou S et al., Nat Commun - This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to in...
8 Dec 202517min
