221: Allele-resolved nanopore tour of the human placental methylome
Kindlova M et al., Nat Commun - Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas...
7 Dec 202520min
220: AML cell states reveal NPM1 immune-evasion subtypes
Lilljebjörn H et al., Nat Commun - Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic st...
6 Dec 202515min
219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
Hällqvist J et al., Nature Communications - Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that conv...
6 Dec 202516min
218: SIM1 and the multi-ancestry genomics of erectile dysfunction
Bright U et al., Nat Commun - A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfu...
4 Dec 202519min
217: Multiscale triads of meiotic crossover patterning
White MA et al., Nature Communications - FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers of evenly spaced protein triads that c...
3 Dec 202517min
216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair
Makins K et al., Nature Communications - This episode reviews a study showing that 53BP1-RIF1 and DNA-PKcs have different genetic relationships across blunt end joining, deletion patterns, HDR, and ra...
2 Dec 202518min
215: Protein Set Transformer for high-diversity viromics
Martin et al., Nat Commun (2025) - Protein Set Transformer (PST) is a protein-based genome language model that represents genomes as sets of proteins to improve genome and protein representations acro...
1 Dec 202520min
214: PI(4,5)P2 Asymmetry Accelerates FGF2 Secretion
Kaur M et al., Nature Communications - Reconstitution of asymmetric membranes and matched cell experiments show that transbilayer asymmetry of PI(4,5)P2 lowers the energetic barrier for FGF2-driven li...
30 Nov 202518min
