213: BRAIN-MAGNET: Functional genomics atlas for non-coding variants
Deng R et al. - BRAIN-MAGNET couples a ChIP-STARR-seq atlas of 148,198 neural regulatory elements with a validated convolutional neural network to predict enhancer activity and prioritize disease-rele...
29 Nov 202520min
212: Zonal control of mutant β-catenin tumorigenesis
Raven A et al. - This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer by forcing differentiation to a non-permissive zone 3 fate or, when re...
28 Nov 202516min
211: Retention Elements in Cancer Cells
Sankar et al. - This episode explores the discovery of genetic elements that promote the retention of extrachromosomal DNA (ecDNA) in cancer cells, enhancing their survival and evolution. Key terms: e...
27 Nov 202519min
210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma
Tumour-Reactive CD8 T Cell Clusters in Human Melanoma Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09754-w License:This episode is based on an open-...
26 Nov 202518min
209: PERT: Prime Editing tRNAs for Nonsense Mutations
PERT: Prime Editing tRNAs for Nonsense Mutations Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09732-2 License:This episode is based on an open-acces...
25 Nov 202516min
208: ZAK, Collided Ribosomes, and the Stress Switch
ZAK, Collided Ribosomes, and the Stress Switch Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09772-8 License:This episode is based on an open-access ...
24 Nov 202515min
207: Semantic Design of de novo Genes with Evo
Semantic Design of de novo Genes with Evo Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09749-7 License:This episode is based on an open-access artic...
24 Nov 202515min
206: Wild Birds and the North American H5N1 Epizootic
Wild Birds and the North American H5N1 Epizootic Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under the Cr...
22 Nov 202517min
