426: ProtoCloud — Prototypical self-explaining model for single-cell analysis
Guo K et al., Cell Genomics - ProtoCloud is a self-explaining deep generative model that embeds single cells around cell-type-specific prototypes to deliver accurate, uncertainty-aware cell type annot...
23 Jul 16min
425: BEAM: Bayesian reconstruction of metastatic migration histories
Staklinski SJ et al., Cell Genomics 6, 101193 (2026) - This episode explores BEAM, a Bayesian framework built on BEAST 2 that jointly infers cell-lineage phylogenies and tissue-migration graphs from C...
23 Jul 23min
424: LECA's Ancient Interactome and Modern Disease
Cox RM et al., Cell Genomics 6, 101254 - Cox et al. reconstruct a conserved protein interaction network for the last eukaryotic common ancestor using >26,000 mass spectrometry experiments across 31 sp...
23 Jul 12min
423: How GRN Topology Shapes the Genetic Architecture of Expression
Aguirre M et al., Cell Genomics - Aguirre et al. use simulated gene regulatory networks and a linear structural equation model to show how sparsity, modularity, and hub regulators shape the genome-wid...
22 Jul 25min
422: Germline rDNA Variants and Human Complex Traits
Rodriguez-Algarra F et al., Cell Genomics - This episode examines a large-scale analysis of germline ribosomal DNA (rDNA) variation in ~500,000 UK Biobank genomes that identifies high-confidence rDNA ...
22 Jul 20min
421: Pre-existing Cell States Predict Multi-Treatment Resistance
Schaff DL et al., Cell Genomics - Schaff et al. use multi-treatment clonal tracing combined with single-cell RNA-seq to show that rare, pre-existing transcriptional states in melanoma predict resistan...
22 Jul 24min
420: NOTCH2NL duplications: diversity, regulation, and human-specific changes
Real TD et al., Cell Genomics - This episode examines a long-read sequencing study that resolves the complex NOTCH2NL segmental duplications on human chromosome 1, traces independent duplications in a...
21 Jul 22min
419: The Single-Cell Pediatric Cancer Atlas
Hawkins AG et al., Cell Genomics - This episode summarizes Hawkins et al.'s presentation of the Single-Cell Pediatric Cancer Atlas (ScPCA) Portal, a publicly available resource that provides uniformly...
20 Jul 24min
