410: Nucleotide diversity is a poor predictor of short-term adaptive potential
Abson KL et al., PNAS - A cross-species synthesis and theory paper showing that simple molecular diversity metrics poorly predict short-term adaptive potential. The authors compiled >2,100 quantitativ...
8 Jul 21min
409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli
Shin J et al., PNAS - This episode examines a large transcriptome compendium (PRECISE-NP881) that profiles E. coli K-12 MG1655 across 43 carbon substrates. Independent component analysis resolved 137 ...
7 Jul 27min
408: Tau, mitochondria, and the fusion switch
Tsakiria E et al., Proceedings of the National Academy of Sciences (PNAS) - Using Tau knockout mice and the C. elegans PTL-1 deletion, this study shows that loss of wild-type Tau promotes a conserved ...
6 Jul 24min
407: SLC11A2 withholds metals from Salmonella in the gut epithelium
Norberg ES et al., Proceedings of the National Academy of Sciences - Using metal‑responsive fluorescent Salmonella reporters, calf intestinal loops, and CRISPR edited epithelial cells, this study show...
5 Jul 21min
406: Temperature & Age Shape Gut Susceptibility to HCoV-229E
Synowiec A et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study using fetal, pediatric, and adult human intestinal enteroids to show that physiological t...
1 Jul 19min
405: PRDM9 and the Hotspot Trade-off
Úbeda F et al., Proceedings of the National Academy of Sciences (PNAS) - A population-genetic model explains why sequence-specific PRDM9-guided recombination hotspots can evolve and persist alongside ...
1 Jul 23min
404: RUNA Reveals Surface DNA on Exosomes
Bošković F et al., Proceedings of the National Academy of Sciences - This study introduces RUNA, a reversible chemistry that selectively labels uridine/thymidine to map nucleic acids across membranes,...
30 Jun 21min
403: HRD-GIS Evidence for BRCA1/2 Variant Classification
Schnaiter et al et al., The American Journal of Human Genetics - Schnaiter et al. pooled Myriad MyChoice HRD+ CDx results from four cohorts (4,943 HGOC tumors) to test whether tumor HRD-related genomi...
26 Jun 22min
