418: Translating GWAS Across Scales
Felici B et al., Cell Genomics - A concise review of how post-GWAS methods are being used to move from statistical associations to translational insights by integrating drug-target prioritization, sin...
18 Jul 24min
417: Hidden Mosaic: Parental Postzygotic Mutations in 12,015 Trios
Garcia-Salinas OI et al., The American Journal of Human Genetics - Garcia-Salinas et al. develop a bioinformatic pipeline to recover early parental postzygotic mutations (PZMs) from standard-depth (~3...
18 Jul 21min
416: HGT-chimeras: fusion across the tree of life
Kapoor RR et al., PNAS - A systematic screen of 319 arthropod genomes reveals genes formed by in‑frame fusion of horizontally transferred nonmetazoan sequences with endogenous metazoan regions. Many o...
18 Jul 26min
415: ERG Unlocked: Targeting the PNT Domain with PBITE-1
PNAS - This episode breaks down a PNAS study that identifies a druggable pocket in the ERG transcription factor PNT domain and describes PBITE-1, a small-molecule probe that binds this pocket to inhib...
18 Jul 25min
414: Durability of Cas9 Gene Drives in Anopheles: A 2‑Year Cage Study
Carballar-Lejarazúa R et al., PNAS (2026) - This episode summarizes a 2-year, 35-generation multireplicate cage trial evaluating three autonomous Cas9/gRNA gene-drive strains (AcTP13, AcTP43 in Anophe...
17 Jul 31min
413: Rpc34 WH2 dynamics in RNA polymerase III
Wu J-S et al., PNAS - A PNAS study using smFRET and nano-positioning triangulation maps dynamic positioning of the Rpc34 WH2 domain in yeast Pol III elongation complexes and presents a thiol-capping S...
12 Jul 15min
412: Fault Lines in Forensic Proficiency Testing
Scurich N et al., PNAS - A concise breakdown of a PNAS perspective that analyzes forensic proficiency testing practices using the 2023 CTS firearms test as a case study. The authors identify test desi...
12 Jul 28min
411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity
Nihata A et al., PNAS - This PNAS study describes the development of EKV, a humanized dividing cell line that propagates bona fide sporadic CJD (sCJD) prions, and the Human Prion Assay (HPA), a cell-b...
9 Jul 26min
